> [!info] Metadata > YAML Frontmatter > ``` > --- > type: page > aliases: > - medial prefrontal cortex (mPFC) > - medial prefrontal cortex > - mPFC > up: > - "[[Prefrontal Cortex]]" > publish: true > --- > ``` Region of the [[Prefrontal Cortex]] on the medial surface of the frontal lobe, encompassing areas like the [[Anterior Cingulate Cortex|Anterior Cingulate Cortex (ACC)]], [[prelimbic cortex]], and [[infralimbic cortex]] in rodents, or corresponding human subregions such as the [[ventromedial prefrontal cortex]]. It integrates sensory, emotional, and cognitive information to regulate executive functions, decision-making, and social behavior. ## Key Functions mPFC plays roles in [[Working Memory]], where dorsal regions support delay-period activity; [[Decision-Making]], including value processing and risk assessment via connections to [[orbitofrontal cortex]] and [[striatum]]; cognitive flexibility, such as set-shifting and reversal learning; and [[Attention]], modulating impulsivity through subthalamic nucleus links. Ventral mPFC handles emotional and autonomic responses, like fear extinction and interoception, while dorsal areas focus on action control. ## Sources - The Role of Medial Prefrontal Cortex in Memory and Decision Making https://pmc.ncbi.nlm.nih.gov/articles/PMC3562704/ - Medial Prefrontal Cortex https://www.sciencedirect.com/topics/medicine-and-dentistry/medial-prefrontal-cortex - The role of the medial prefrontal cortex in cognition, ageing and dementia https://academic.oup.com/braincomms/article/3/3/fcab125/6296836 - Medial prefrontal cortex in neurological diseases - PMC - NIH https://pmc.ncbi.nlm.nih.gov/articles/PMC6766703/ - Medial Prefrontal Cortex - an overview https://www.sciencedirect.com/topics/psychology/medial-prefrontal-cortex - Frontiers | The role of medial prefrontal cortex in early social cognition https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2013.00340/full